[大肠杆菌四环素抗性突变体对萘啶酸的抗性]
[Resistance to nalidixic acid in tetracycline-resistant mutants of E. coli].
作者信息
Khanina M F, Gromova T G, Terekhov A A
出版信息
Antibiotiki. 1975;20(12):1099-104.
PMID:773284
Abstract
The studies on the effect of nalidixic acid (negram) on the synthesis of DNA and determination of its minimal inhibitory concentrations revealed a regular decrease in the sensitivity levels to negram of the tetracycline resistant mutants selected on media with tetracycline. Heterogene ty of the tetracycline resistant mutants to EDTA showed that one of the causes of insensitivity of the mutants to negram was a change in the surface structures of the microbial cell.
摘要
关于萘啶酸（Negram）对DNA合成的影响及其最低抑菌浓度测定的研究表明，在含四环素的培养基上筛选出的四环素抗性突变体对Negram的敏感性水平呈规律性下降。四环素抗性突变体对EDTA的异质性表明，突变体对Negram不敏感的原因之一是微生物细胞表面结构的改变。
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