Hrebenda J, Heleszko H, Brzostek K, Bielecki J
J Gen Microbiol. 1985 Sep;131(9):2285-92. doi: 10.1099/00221287-131-9-2285.
A new mutation, nalD, determining resistance of Escherichia coli to nalidixic acid (NAL) is reported. The nalD mutant described is resistant to NAL at 37 degrees C but sensitive at 30 degrees C. It is defective in penetration of NAL and glycerol through the outer membrane at 37 degrees C. The nalD mutation is located half-way between 89 and 89.5 min on the E. coli genetic map.
报道了一种新的突变体nalD，它可决定大肠杆菌对萘啶酸（NAL）的抗性。所描述的nalD突变体在37℃时对NAL具有抗性，但在30℃时敏感。它在37℃时通过外膜渗透NAL和甘油存在缺陷。nalD突变位于大肠杆菌遗传图谱上89分钟至89.5分钟之间的中间位置。
