Ishida M, Yokoi N, Okuzawa J, Maeda K, Kinoshita S
Department of Ophthalmology, Kyoto Prefectural University of Medicine, Japan.
Nippon Ganka Gakkai Zasshi. 1995 Mar;99(3):308-11.
Corneal autofluorescence was investigated by fluorophotometry in patients with non-insulin-dependent diabetes mellitus and healthy volunteers, and evaluated as to its correlation with diabetic retinopathy. The corneal autofluorescence of diabetes patients, which was significantly higher than that of healthy controls, correlated significantly with the severity of retinopathy. In addition, the corneal autofluorescence of burned-out retinopathy patients was significantly lower than that of proliferative retinopathy patients. These results suggest that corneal autofluorescence is correlated with retinal ischemia and that corneal autofluorescence can be an indicator of the activity of diabetic retinopathy. Corneal autofluorescence may originate in the accumulation of some factor induced by retinal ischemia within the corneal stroma.
通过荧光光度法对非胰岛素依赖型糖尿病患者和健康志愿者的角膜自发荧光进行了研究，并评估了其与糖尿病视网膜病变的相关性。糖尿病患者的角膜自发荧光显著高于健康对照组，且与视网膜病变的严重程度显著相关。此外，已消退视网膜病变患者的角膜自发荧光显著低于增殖性视网膜病变患者。这些结果表明，角膜自发荧光与视网膜缺血相关，且角膜自发荧光可作为糖尿病视网膜病变活动的一个指标。角膜自发荧光可能源于视网膜缺血诱导的某些因子在角膜基质内的积累。
