Stolovitch C, Alster Y, Loewenstein A, Lazar M
Department of Ophthalmology, Tel-Aviv Medical Center, Israel.
Am J Ophthalmol. 1995 May;119(5):637-9. doi: 10.1016/s0002-9394(14)70222-3.
Because the usual length of time to instill two drops of cyclopentolate 1% (five to ten minutes) is time-consuming and inconvenient to clinical staff as well as to the child and the child's parents, we investigated the influence of the time interval between the instillation of the two drops on refraction and mydriasis in children.
We conducted a crossover study on 48 children at the Tel-Aviv Medical Center. Gender, iris color, ethnic origin, and age were recorded. Two cyclopentolate 1% eyedrops were instilled at a one- or five-minute time interval. Retinoscopy was performed and the mydriatic effect was recorded. One week later, the procedure was repeated, this time with a different time interval.
The time interval between the instillation of the two drops had no significant influence on retinoscopy results (P = .65 and P = .50 for right and left eyes, respectively) or on pupil dilation (P = .377 and P = .113 for right and left eyes, respectively).
Instilling two drops of cyclopentolate 1% one minute apart is as effective as instilling them five minutes apart.
由于滴入两滴1%环喷托酯通常所需的时间（五到十分钟）既耗时，又给临床工作人员以及儿童及其家长带来不便，我们研究了两滴药物滴入的时间间隔对儿童验光和散瞳的影响。
我们在特拉维夫医疗中心对48名儿童进行了一项交叉研究。记录了性别、虹膜颜色、种族和年龄。以一分钟或五分钟的时间间隔滴入两滴1%环喷托酯眼药水。进行了视网膜检影并记录了散瞳效果。一周后，重复该操作，这次采用不同的时间间隔。
两滴药物滴入的时间间隔对视网膜检影结果（右眼和左眼的P值分别为0.65和0.50）或瞳孔散大（右眼和左眼的P值分别为0.377和0.113）均无显著影响。
相隔一分钟滴入两滴1%环喷托酯与相隔五分钟滴入的效果相同。
