Lalanne B, Baubion O, Sezeur A, Tricot C, Gaudy J H
Service de Chirurgie Générale et Digestive, Hôpital Rothschild, Paris.
Ann Chir. 1994;48(11):1025-8.
One of the treatments for pain in patients with unresectable pancreatic cancer is chemical splanchnicectomy by phenol. We report two cases of severe cardiac arrhythmia followed by circulatory arrest, during intraoperative chemical splanchnicectomy. The cardiac toxicity of phenol is known in plastic surgery (face peeling). The reasons for this toxicity are not well known. We recommend that phenol be replaced by alcohol during chemical splanchnicectomy, because of its safety.
对于无法切除的胰腺癌患者，疼痛治疗方法之一是用苯酚进行化学性内脏神经切除术。我们报告了两例在术中进行化学性内脏神经切除时出现严重心律失常继而循环骤停的病例。苯酚的心脏毒性在整形外科（面部换肤）中是已知的。这种毒性的原因尚不清楚。由于酒精的安全性，我们建议在化学性内脏神经切除术中用酒精取代苯酚。
