可吸收自增强聚乙交酯膜对干骺端骨的影响。一项在大鼠身上的实验研究。

The effect of absorbable self-reinforced polyglycolide membrane on metaphyseal bone. An experimental study on rats.

作者信息

Ashammakhi N, Mäkelä E A, Vihtonen K, Rokkanen P, Törmälä P

机构信息

Department of Orthopaedics and Traumatology, Helsinki University Central Hospital, Finland.

出版信息

Ann Chir Gynaecol. 1994;83(4):328-34.

PMID:7733617

Abstract

The effect of self-reinforced polyglycolide (SR-PGA) absorbable membranes on metaphyseal bone was studied in eighty-seven rats. SR-PGA membranes, 0.15 mm thick, were implanted on the femoral metaphyseal bone: on the periosteum, and directly on bone after periosteal stripping. In a control group, only periosteal stripping was performed. The rats were killed after 1, 3, 6, 12 and 24 weeks. Fibrous tissue formation around the implant, periosteal thickening and new bone formation occurred more extensively when SR-PGA membranes were implanted directly on bone after periosteal stripping. Fibrous tissue invaded the membranes. At twenty-four weeks, few fibre remnants were found embedded in a rim of fibrous tissue. No locally adverse reactions were recorded. Polyglycolide (PGA) appeared to have a positive inductive effect on new bone formation.

摘要

在八十七只大鼠中研究了自增强聚乙交酯（SR-PGA）可吸收膜对干骺端骨的影响。将厚度为0.15毫米的SR-PGA膜植入股骨干骺端骨：置于骨膜上，以及在骨膜剥离后直接置于骨上。在对照组中，仅进行骨膜剥离。在1、3、6、12和24周后处死大鼠。当SR-PGA膜在骨膜剥离后直接植入骨上时，植入物周围的纤维组织形成、骨膜增厚和新骨形成更为广泛。纤维组织侵入膜内。在二十四周时，在纤维组织边缘发现少量残留纤维。未记录到局部不良反应。聚乙交酯（PGA）似乎对新骨形成有积极的诱导作用。