Tal M, Ammar D A, Karpuj M, Krizhanovsky V, Naim M, Thompson D A
Department of Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
Biochem Biophys Res Commun. 1995 Apr 17;209(2):752-9. doi: 10.1006/bbrc.1995.1563.
We have used a homology based approach to identify G protein-coupled receptors preferentially expressed in retinal and taste cells. Rat and bovine sequences encoding a novel G protein-coupled receptor have been isolated. Analysis indicates that while the protein sequence is most similar to the receptors for somatostatin and opiates, it is unlikely to be a subtype of these receptors. Northern and RNase protection analysis indicates that the gene is preferentially expressed in neural and sensory tissues.
我们采用了一种基于同源性的方法来鉴定在视网膜和味觉细胞中优先表达的G蛋白偶联受体。已分离出编码一种新型G蛋白偶联受体的大鼠和牛的序列。分析表明，虽然该蛋白质序列与生长抑素和阿片类药物的受体最为相似，但它不太可能是这些受体的亚型。Northern印迹和核糖核酸酶保护分析表明，该基因在神经和感觉组织中优先表达。
