Nagahara A H, Otto T, Gallagher M
Department of Psychology, University of North Carolina at Chapel Hill, USA.
Behav Neurosci. 1995 Feb;109(1):3-9. doi: 10.1037//0735-7044.109.1.3.
The effects of entorhinal-perirhinal lesions in rats were studied with 2 versions of a place learning task in the Morris water maze. These lesions impaired performance on a multiple-trial task (3 days of 6 trials and a probe trial). This assessment was followed by a task in which rats were repeatedly trained to find novel locations with a variable delay (30 s or 5 min) imposed between each sample trial and retention test. Entorhinal-perirhinal damage produced a delay-dependent deficit in spatial memory: Rats with lesions were impaired at the 5-min delay relative to the control group and to their own performance at 30 s. These findings are discussed in relationship to memory impairment after entorhinal damage and spatial learning deficits observed after hippocampal damage.
利用莫里斯水迷宫中的两种版本的位置学习任务，研究了大鼠内嗅-嗅周损伤的影响。这些损伤损害了多试验任务（6次试验，为期3天，并进行一次探测试验）的表现。在此评估之后，进行了一项任务，即反复训练大鼠寻找新位置，在每次样本试验和保持测试之间设置可变延迟（30秒或5分钟）。内嗅-嗅周损伤导致空间记忆出现延迟依赖性缺陷：与对照组相比，以及与它们自己在30秒时的表现相比，有损伤的大鼠在5分钟延迟时表现受损。结合内嗅损伤后的记忆损害以及海马损伤后观察到的空间学习缺陷，对这些发现进行了讨论。
