Wiig K A, Bilkey D K
Department of Psychology, University of Otago, Dunedin, New Zealand.
Behav Brain Res. 1994 Jul 29;63(1):101-9. doi: 10.1016/0166-4328(94)90055-8.
Rats with bilateral, electrolytic lesions of the perirhinal cortex and sham operated control rats were tested in the Morris water maze, a procedure which has repeatedly been shown to be sensitive to hippocampal and limbic system dysfunction. The results of the present study demonstrate that perirhinal lesioned rats were mildly impaired on this task. The lesioned animals took significantly longer than controls to locate the hidden platform during place navigation acquisition, and had significantly larger heading errors across the entire experimental procedure. In addition, these lesioned animals made fewer platform crossings than control rats during the probe trials. These results suggest that the perirhinal cortex, like the anatomically related entorhinal cortex and hippocampus, may be involved in mnemonic processing.
对双侧梨状周皮层有电解损伤的大鼠以及假手术对照组大鼠进行了莫里斯水迷宫测试，该测试已反复证明对海马体和边缘系统功能障碍敏感。本研究结果表明，梨状周皮层损伤的大鼠在此任务中表现出轻度受损。在位置导航获取过程中，损伤动物找到隐藏平台的时间明显长于对照组，并且在整个实验过程中航向误差明显更大。此外，在探索性试验中，这些损伤动物穿越平台的次数比对照大鼠少。这些结果表明，梨状周皮层与解剖学上相关的内嗅皮层和海马体一样，可能参与记忆处理。
