Svanberg L, Hellekant C
Jpn J Antibiot. 1977 Dec;30 Suppl:57-69.
Bronchial artery infusion of mitomycin C might be very effective in treating minor tumors but, as a rule, less effective in the treatment of larger tumors. In order to achieve improved effect of treatment, 21 cases (stage II-III/TNM) were given supplementary chemotherapy with bleomycin or vincristine-bleomycin. Preoperative treatment was given to 11 cases in which indications for surgical treatment were primarily uncertain or absent. The other group consisted of 10 patients with inoperable lesions. Combined treatment has proved to have a strong but mainly local effect. Repeated courses (up to 5 times) were more effective than a single one. The regional effect, i.e: on overgrowth onto the mediastinum, pericardium or thoracic wall was weak. The system effect was negligible. Penetrating data about objective response are given.
支气管动脉灌注丝裂霉素C对治疗较小肿瘤可能非常有效，但通常对较大肿瘤的治疗效果较差。为提高治疗效果，对21例（II - III期/TNM）患者采用博来霉素或长春新碱 - 博来霉素进行辅助化疗。对11例手术治疗指征初步不确定或不存在的患者进行了术前治疗。另一组由10例无法手术的病变患者组成。联合治疗已证明具有强大但主要是局部的效果。重复疗程（最多5次）比单次疗程更有效。对纵隔、心包或胸壁的过度生长等区域效应较弱。全身效应可忽略不计。给出了关于客观反应的详细数据。
