Vera Sempere F J, Botella Rodríguez M S, Aparisi Mocholi F, Morera Pérez C
Servicio de Anatomía Patológica, Hospital Universitario La Fe, Valencia.
Acta Otorrinolaringol Esp. 1995 Jan-Feb;46(1):67-70.
A clinic-pathological study of a 12 year-old male diagnosed of non-differentiated nasopharyngeal carcinoma (NPC) was carried out. The patients presented secondary hypertrophic osteoarthropathy prior to the development of lung metastases. Hypertrophic osteoarthropathy is a clinic-radiological syndrome characterized by a neoformation of periosteal bone, fundamentally located in long bones and distal ends of metacarpal bones. Polyarticular and synovial involvement is also observed. Association between NPC and hypertrophic osteoarthropathy is uncommon and appears to suggest the existence of metastatic spread (probably to the lung), particularly in young patients.
对一名被诊断为未分化鼻咽癌（NPC）的12岁男性患者进行了临床病理研究。该患者在发生肺转移之前出现了继发性肥大性骨关节病。肥大性骨关节病是一种临床-放射学综合征，其特征是骨膜骨的新生，主要位于长骨和掌骨远端。也观察到多关节和滑膜受累。NPC与肥大性骨关节病之间的关联并不常见，似乎提示存在转移扩散（可能转移至肺部），尤其是在年轻患者中。
