Rothbarth P H, Kempen B M, Sprenger M J
University Hospital Rotterdam, Department of Virology, The Netherlands.
Am J Respir Crit Care Med. 1995 May;151(5):1682-5; discussion 1685-6. doi: 10.1164/ajrccm/151.5_Pt_1.1682.
Although influenza is generally seen as an important cause of excess mortality in patients with asthma or chronic obstructive pulmonary disease (COPD), this mortality is nearly exclusively present in patients over the age of 60. Morbidity in patients with asthma or COPD is related to respiratory infections, including influenza. Vaccination against influenza has proven to be effective in nursing home populations, decreasing both mortality and morbidity during epidemics of influenza A. In younger patients with asthma or COPD, however, the effect of vaccination is more ambiguous. Exacerbation of respiratory disease is not due to influenza vaccination (except in allergy to chicken protein), from which we can conclude that influenza vaccination is a safe method to prevent a potentially serious respiratory infection in patients with asthma or COPD.
虽然流感通常被视为哮喘或慢性阻塞性肺疾病（COPD）患者超额死亡率的一个重要原因，但这种死亡率几乎只出现在60岁以上的患者中。哮喘或COPD患者的发病与包括流感在内的呼吸道感染有关。事实证明，流感疫苗接种对疗养院人群有效，可降低甲型流感流行期间的死亡率和发病率。然而，在较年轻的哮喘或COPD患者中，疫苗接种的效果更为模糊。呼吸道疾病的加重并非由流感疫苗接种引起（对鸡蛋白过敏者除外），由此我们可以得出结论，流感疫苗接种是预防哮喘或COPD患者潜在严重呼吸道感染的一种安全方法。
