Lilienfield L S, Rose J C, Princiotto J V
Clin Pharmacol Ther. 1976 Apr;19(4):421-5. doi: 10.1002/cpt1976194421.
A double-blind crossover study was conducted to evaluate the antitussive effectiveness of diphenhydramine (DPH) in chornic coughs related to bronchitis, at doses of 25 and 50 mg every 4 hr for four doses. Both 25- and 50-mg doses caused a statistically and clinically significant reduction in frequency of coughs, compared to placebo. The most frequently reported side effect was drowsiness, principally at the 50-mg dose level. There was little or no apparent correlation between antitussive effectiveness and incidence of drowsiness, however, suggesting that the two effects were pharmacologically unrelated.
进行了一项双盲交叉研究，以评估苯海拉明（DPH）对与支气管炎相关的慢性咳嗽的镇咳效果，每4小时服用25毫克和50毫克，共服用四剂。与安慰剂相比，25毫克和50毫克剂量均在统计学和临床上显著降低了咳嗽频率。最常报告的副作用是嗜睡，主要出现在50毫克剂量水平。然而，镇咳效果与嗜睡发生率之间几乎没有明显相关性，这表明这两种作用在药理上不相关。
