Gritz E R, Shiffman S M, Jarvik M E, Schlesinger J, Charuvastra V C
Clin Pharmacol Ther. 1976 Jun;19(6):773-6. doi: 10.1002/cpt1976196773.
An ascending series of single doses of the narcotic antagonist naltrexone, ranging from 20 to 160 mg, was administered to 8 abstinent former addicts in order to assess agonistic activity and any toxic side effects. There was little alteration of normal body function. Significant, but small, changes in sublingual temperature (0.4 degrees F decrease), and diastolic blood pressure (1.7 mm Hg increase) were induced. Among the battery of tests assessing behavioral or mood-feeling variables, only 2 showed significant between-condition effects: facilitated performance on the Cross-out Test (attention and perception), and a dose-related decrease in Morphine-Benzedrine Group (MBG) scores of the Addiction Research Center Inventory (ARCI) (mild euphoria). On the whole, subjects had few subjective reactions or unpleasant side effects. Naltrexone appears to be a safe, nontoxic medication in the dosage range examined.
为评估激动活性和任何毒副作用，对8名已戒毒的 former addicts 单次服用剂量递增的麻醉拮抗剂纳曲酮，剂量范围为20至160毫克。正常身体功能几乎没有改变。诱导出了显著但微小的舌下温度变化（下降0.4华氏度）和舒张压变化（升高1.7毫米汞柱）。在评估行为或情绪感受变量的一系列测试中，只有2项显示出显著的条件间效应：在划消测验（注意力和感知）中表现得到改善，以及成瘾研究中心量表（ARCI）的吗啡 - 苯丙胺组（MBG）得分出现与剂量相关的下降（轻度欣快感）。总体而言，受试者几乎没有主观反应或不愉快的副作用。在所研究的剂量范围内，纳曲酮似乎是一种安全、无毒的药物。
