Mitchell H M, Lee A
School of Microbiology and Immunology, University of New South Wales, Sydney, Australia.
Eur J Gastroenterol Hepatol. 1994 Dec;6 Suppl 1:S11-6.
To outline the evidence for and against ulcerogenic strains of Helicobacter pylori.
Although H. pylori is now well established as a predisposing factor in peptic ulcer disease the question of why only a minority of people infected with H. pylori develop peptic ulceration remains unanswered and is the subject of much controversy.
Perhaps the most accepted view to date is the belief that there are ulcerogenic strains of H. pylori which produce a specific cytotoxin responsible for the ulceration.
At the present time the case for ulcerogenic strains is not proven and the differences between H. pylori infected peptic ulcer patients and H. pylori infected non-ulcer subjects may relate simply to host factors.
概述支持和反对幽门螺杆菌致溃疡菌株的证据。
尽管幽门螺杆菌现已被确认为消化性溃疡疾病的一个诱发因素，但为何仅有少数感染幽门螺杆菌的人会发生消化性溃疡这一问题仍未得到解答，且存在诸多争议。
也许迄今为止最被认可的观点是，存在幽门螺杆菌致溃疡菌株，其产生一种导致溃疡的特定细胞毒素。
目前，致溃疡菌株的情况尚未得到证实，幽门螺杆菌感染的消化性溃疡患者与幽门螺杆菌感染的非溃疡患者之间的差异可能仅与宿主因素有关。
