Newman D J, Thakkar H, Medcalf E A, Gray M R, Price C P
Department of Clinical Biochemistry, London Hospital Medical College, England, UK.
Clin Nephrol. 1995 Feb;43(2):104-9.
We have investigated the replacement of urine total protein estimations for the assessment of glomerular permeability, by the measurement of urine albumin excretion using a latex particle enhanced immunoturbidimetric assay. An initial screen was performed using Albustix to assess the sample pre-dilution necessary for immunoanalysis. A total of 167 24-hour urine samples were analysed and urine albumin concentration correlated well with that of urine total protein (r = 0.93) over the range 0-16,800 mg/l. This protocol provides a more cost effective and analytically valid assessment of glomerular permeability.
我们使用乳胶颗粒增强免疫比浊法测量尿白蛋白排泄量，研究了用其替代尿总蛋白测定来评估肾小球通透性的情况。最初使用尿蛋白试纸条进行筛查，以评估免疫分析所需的样品预稀释。共分析了167份24小时尿液样本，在0-16,800mg/l范围内，尿白蛋白浓度与尿总蛋白浓度相关性良好（r=0.93）。该方案为肾小球通透性提供了更具成本效益且分析有效的评估。
