Djoenaidi W, Notermans S L, Gabreëls-Festen A A, Lilisantoso A H, Sudanawidjaja A
Department of Neurology, Airlangga University, Faculty of Medicine, Dr. Soetomo Hospital, Surabaya, Indonesia.
Electromyogr Clin Neurophysiol. 1995 Jan-Feb;35(1):53-60.
Chickens fed with the same composition of diet as our low income beriberi polyneuropathic patients, developed clinical symptoms of thiamine deficiency in 22.3 +/- 6.3 days. There appeared to be a body store of thiamine which is utilized during a period of deficient intake. Haemoglobin content and serum albumin did not change appreciably during thiamine deficiency. The blood thiamine content was low and the thiamine pyrophosphate (TPP) effect increased to more than 25 percent during the development of the beriberi polyneuropathy, which resumed after one week on thiamine tetrahydrofurfuryl disulfide (TTFD) treatment. However, the clinical features gradually improved after about one month. Neurophysiological findings including somatosensory evoked potentials (SSEPs) and neuromorphological studies of the peroneal and sciatic nerves were compatible with a major degree of axonal degeneration and secondary minimal segmental demyelination. We may conclude that the experimentally induced beriberi polyneuropathy in chickens seems a good model for studying these forms of neuropathy in view of diagnosis and treatment.
给鸡喂食与我们低收入脚气性多发性神经病患者相同成分的饮食后，在22.3±6.3天出现了硫胺素缺乏的临床症状。似乎存在硫胺素的身体储备，在摄入不足期间会被利用。在硫胺素缺乏期间，血红蛋白含量和血清白蛋白没有明显变化。在脚气性多发性神经病发展过程中，血液硫胺素含量较低，硫胺素焦磷酸（TPP）效应增加到超过25%，在使用四氢糠基二硫化硫胺（TTFD）治疗一周后恢复。然而，临床症状在大约一个月后逐渐改善。神经生理学发现，包括体感诱发电位（SSEP）以及腓总神经和坐骨神经的神经形态学研究，与主要程度的轴突变性和继发性轻度节段性脱髓鞘相符。鉴于诊断和治疗，我们可以得出结论，实验诱导的鸡脚气性多发性神经病似乎是研究这些形式神经病的良好模型。
