参数变异性与基于生理的药代动力学建模结果的解释
Parameter variability and the interpretation of physiologically based pharmacokinetic modeling results.
作者信息
Spear R C, Bois F Y
机构信息
School of Public Health, University of California, Berkeley 94720, USA.
出版信息
Environ Health Perspect. 1994 Dec;102 Suppl 11(Suppl 11):61-6. doi: 10.1289/ehp.94102s1161.
Abstract
For the past several years we have been working with models of benzene distribution and metabolism, principally in the rat, but more recently in humans. Our biologically related objectives have been primarily to assist our laboratory-based colleagues in their quest for understanding of the mechanisms by which benzene exerts its toxic action. A secondary goal has been to develop or adapt models useful in risk assessment applications. We have also had methodological goals that relate to applications of sensitivity analysis on the one hand, but more fundamentally to the connection between experimental data and model structure and parameterization. This paper presents an overview of our work in these areas.
摘要
在过去的几年里，我们一直在研究苯的分布和代谢模型，主要以大鼠为研究对象，但最近也开始研究人类。我们与生物学相关的目标主要是协助我们在实验室工作的同事，以了解苯发挥其毒性作用的机制。第二个目标是开发或改进适用于风险评估应用的模型。我们还有一些方法学目标，一方面涉及敏感性分析的应用，但更根本的是涉及实验数据与模型结构及参数化之间的联系。本文概述了我们在这些领域的工作。
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本文引用的文献
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Pharmacokinetics of benzene.苯的药代动力学
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Mechanisms of benzene carcinogenesis: application of a physiological model of benzene pharmacokinetics and metabolism.苯致癌机制：苯药代动力学和代谢生理模型的应用
Toxicol Lett. 1991 May;56(3):283-98. doi: 10.1016/0378-4274(91)90157-2.
7
Comparison of three physiologically based pharmacokinetic models of benzene disposition.苯代谢的三种生理药代动力学模型的比较。
Toxicol Appl Pharmacol. 1991 Aug;110(1):79-88. doi: 10.1016/0041-008x(91)90291-l.
8
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