Novis B H, Duys P, Barbezat G O, Clain J, Bank S, Terblanche J
Gut. 1976 Apr;17(4):258-63. doi: 10.1136/gut.17.4.258.
The value of emergency upper gastrointestinal fibre-endoscopy, followed where required by the use of a modified Sengstaken tube, was studied during 84 episodes of acute bleeding in 75 patients who had evidence of portal hypertension with varices. The portal hypertension was due to alcoholic cirrhosis in 80% and to cryptogenic cirrhosis in 9% of the patients. By definition, varices were present in all patients, but in only 66% of episodes were the varices the cause of the bleed. The correct diagnosis of the source of bleeding was made at endoscopy in 89%. A Boyce modification of the Sengstaken-Blakemore tube was passed in 73% of the episodes of variceal bleeding. It effectively stopped the bleeding primarily in 85% of patients but was successful as a final definitive measure only in 46%. Furthermore, only 40% of the patients in whom the tube was passed, survived. Mortality rate could be related to the severity of the bleed and to hepatocellular dysfunction. Survival increased from 23% in those patients with jaundice, ascites, and encephalopathy on admission to 92% in those without these manifestations. The in-hospital survival rate was 52% in patients bleeding from varices and 64% in those bleeding from other causes, with an overall survival rate of 56%, indicating the poor prognosis in cirrhotic patients with gastrointestinal bleeding, irrespective of the cause.
对75例有门静脉高压伴静脉曲张证据的患者在84次急性出血发作期间进行了研究,探讨了紧急上消化道纤维内镜检查的价值,并在必要时使用改良的Sengstaken管。80%的患者门静脉高压由酒精性肝硬化引起,9%由隐源性肝硬化引起。根据定义,所有患者均存在静脉曲张,但仅66%的出血发作是由静脉曲张引起的。内镜检查对出血来源的正确诊断率为89%。73%的静脉曲张出血发作使用了Boyce改良的Sengstaken-Blakemore管。它主要在85%的患者中有效止血,但仅在46%的患者中作为最终确定性措施成功止血。此外,插管患者中只有40%存活。死亡率可能与出血严重程度和肝细胞功能障碍有关。入院时伴有黄疸、腹水和肝性脑病的患者生存率从23%提高到无这些表现的患者的92%。静脉曲张出血患者的院内生存率为52%,其他原因出血患者的院内生存率为64%,总体生存率为56%,这表明肝硬化患者发生胃肠道出血,无论原因如何,预后都很差。