Katayama I
Department of Dermatology, Kitasato University School of Medicine, Sagamihara, Japan.
J Dermatol. 1995 Mar;22(3):186-90. doi: 10.1111/j.1346-8138.1995.tb03368.x.
Recurrent purpuric lesions are occasionally seen in patients with Sjögren syndrome. Hypergammaglobulinemia is one of the underlying precipitating factors of this condition. Clinical and histopathological analyses were performed on 5 cases of hypergammaglobulinemic purpura associated with Sjögren's syndrome, and the effects of immunomodulatory therapy were evaluated with regards to these conditions. Three out of 5 cases were successfully treated with oral gold compound (Auranofin) and one case with a low dose of cyclophosphamide. Episodic purpura subsided two months after initiation of therapy with improved serum IgG levels. Salivary flow and serum amylase levels also improved in some cases. Immunomodulatory therapy may be useful in managing recurrent purpura based on hypergammaglobulinemia associated with Sjögren syndrome.
复发性紫癜性皮损偶尔可见于干燥综合征患者。高球蛋白血症是这种情况的潜在促发因素之一。对5例与干燥综合征相关的高球蛋白血症性紫癜患者进行了临床和组织病理学分析，并评估了免疫调节治疗对这些病症的效果。5例中有3例口服金化合物（金诺芬）治疗成功，1例使用低剂量环磷酰胺治疗成功。开始治疗两个月后，发作性紫癜消退，血清IgG水平有所改善。部分病例的唾液分泌量和血清淀粉酶水平也有所改善。基于与干燥综合征相关的高球蛋白血症，免疫调节治疗可能有助于控制复发性紫癜。
