Kiefer W, Gransow P, Schmidt G, Westphal O
Infect Immun. 1976 May;13(5):1517-8. doi: 10.1128/iai.13.5.1517-1518.1976.
Mice vaccinated with Escherichia coli hybrids experesing Salmonella O antigens were protected against lethal challenge doses of Salmonella strains. Counts of challenge bacteria in mouse organs revealed that a live hybrid vaccine was slightly more efficient than an acetone-killed vaccine.
用表达沙门氏菌O抗原的大肠杆菌杂交体免疫的小鼠对致死剂量的沙门氏菌菌株攻击具有抵抗力。对小鼠器官中攻击细菌的计数显示,活杂交疫苗比丙酮灭活疫苗的效率略高。