实验性沙门氏菌病中的免疫。3. 用鼠伤寒沙门氏菌的活细胞和热灭活细胞进行的比较免疫接种。
Immunity in experimental salmonellosis. 3. Comparative immunization with viable and heat-inactivated cells of Salmonella typhimurium.
作者信息
Germanier R
出版信息
Infect Immun. 1972 May;5(5):792-7. doi: 10.1128/iai.5.5.792-797.1972.
Abstract
Vaccination with viable cells of an avirulent Salmonella typhimurium galE mutant provides mice with solid specific immunity against subsequent infection with a virulent smooth strain. Such a live vaccine is markedly more potent than one prepared from inactivated cells of the virulent smooth strain. The superiority of the live vaccine is particularly well demonstrated when the oral route of application is used. The protective capacity of the galE mutant is based on its ability to synthesize complete smooth-like cell wall lipopolysaccharide in vivo.
摘要
用无毒鼠伤寒沙门氏菌galE突变株的活细胞进行疫苗接种，可使小鼠获得针对后续强毒光滑菌株感染的坚实特异性免疫力。这种活疫苗比由强毒光滑菌株的灭活细胞制备的疫苗明显更有效。当采用口服途径接种时，活疫苗的优越性尤为明显。galE突变株的保护能力基于其在体内合成完整的类似光滑型细胞壁脂多糖的能力。
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