Kolomiytseva I K, Slozhenikina L V, Fialkovskaya L A, Kulagina T P, Markevich L N, Potekhina N I
Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, Russia.
J Biol Phys. 1999 Dec;25(4):325-38. doi: 10.1023/A:1005147109299.
A nonmonotonous relationship between changes of metabolic parameters of tissues and cells of animal and radiation dose were discussed. Under acute irradiation of animals the nonmonotonous dose-response curve for metabolic parameters of tissues and cells were found. The nonmonotonous dose-response curves of metabolic and functional tissues and cells parameters were also revealed upon chronic irradiation of animals at a low dose-rate. The nonmonotonous shape of dose-response curves may be explained on the basis of nonmonotonous kind of the time-course of metabolic response after irradiation. Living cells were supposed to possess a fundamental property in response to action of different stress agents by nonmonotonous changes of cell metabolism. This response was damping in time oscillation of the value of metabolic parameters around the normal level. Amplitudes and periods of oscillations in these changes of metabolic parameters could be observed. In case of chronic irradiation at a low dose-rate the metabolic and functional parameters showed some modified oscillation during irradiation. The nonmonotonous type of changes in metabolic and functional parameters of tissue and cell by chronic low dose-rate irradiation threw some new light on the peculiarities of biological effects of chronic irradiation.
讨论了动物组织和细胞代谢参数变化与辐射剂量之间的非单调关系。在动物急性照射下，发现了组织和细胞代谢参数的非单调剂量反应曲线。在低剂量率慢性照射动物时，也揭示了代谢和功能组织及细胞参数的非单调剂量反应曲线。剂量反应曲线的非单调形状可以基于照射后代谢反应时间进程的非单调类型来解释。活细胞被认为具有一种基本特性，即对不同应激因素的作用通过细胞代谢的非单调变化做出反应。这种反应是代谢参数值围绕正常水平的时间振荡的衰减。可以观察到这些代谢参数变化的振荡幅度和周期。在低剂量率慢性照射的情况下，代谢和功能参数在照射期间表现出一些改变的振荡。慢性低剂量率照射引起的组织和细胞代谢及功能参数的非单调变化类型为慢性照射的生物学效应特性提供了一些新的线索。
