Biver F, Goldman S, François A, De La Porte C, Luxen A, Gribomont B, Lotstra F
Erasme Hospital, Free University of Brussels, Belgium.
J Neurol Neurosurg Psychiatry. 1995 Apr;58(4):502-5. doi: 10.1136/jnnp.58.4.502.
Brain glucose metabolism was investigated with PET and [18F]fluorodeoxyglucose, before and after a bifrontal stereotactic leukotomy in a 37 year old woman with refractory obsessive-compulsive disorder. A bilateral decrease in glucose metabolism was found in the orbital frontal cortex after psychosurgery. Glucose metabolism was decreased to a lesser degree in Brodmann's area 25, in the thalamus, and in the caudate nucleus. Clinical improvement in obsessive-compulsive disorder after stereotactic tractotomy seems to be associated with metabolic changes in the brain, in particular, in the orbital part of the frontal lobe.
在一名患有难治性强迫症的37岁女性患者接受双额叶立体定向白质切断术之前和之后，使用正电子发射断层扫描（PET）和[18F]氟脱氧葡萄糖对其脑葡萄糖代谢进行了研究。术后发现双侧眶额叶皮质的葡萄糖代谢降低。在布罗德曼25区、丘脑和尾状核中，葡萄糖代谢降低的程度较小。立体定向束切断术后强迫症的临床改善似乎与大脑的代谢变化有关，特别是额叶的眶部。
