Ruel M T, Rivera J, Habicht J P
Institute of Nutrition of Central America, Guatemala, Guatemala.
J Nutr. 1995 May;125(5):1222-8. doi: 10.1093/jn/125.5.1222.
Stunting (low length-for-age) is the most widespread manifestation of growth retardation worldwide. Yet, most nutrition programs use weight-for-age for screening of at-risk children. This study tested whether weight-for-age was an effective screening tool in a severely stunted rural Guatemalan population, using data from the INCAP longitudinal supplementation trial (n = 400). Stunting was defined as length-for-age < -2 SD of the National Center for Health Statistics standards at 3 y of age. Sensitivity and specificity analyses and receiver operating characteristics curves were used to compare weight indicators (weight-for-age, weight velocity and weight-for-length) with length (length-for-age and length velocity) and arm and head circumferences measured during early infancy. Length indicators were clearly superior to weight in predicting stunting (Zda test), and velocities were consistently worse than attained growth. Length-for-age at 6 mo had the best performance, followed by length-for-age at 3 mo, and weight-for-age at 6 and at 3 mo. Velocities, weight-for-length and circumferences were all poor predictors of stunting. Using the cutoff of < -1 SD, length-for-age at 3 mo was the best screening indicator for the early detection of growth faltering. Thus, the current use of weight-for-age, which results in large proportions of at-risk children being missed by screening, greatly limits the potential for impact of nutrition interventions.
发育迟缓(年龄别身长较低)是全球范围内生长发育迟缓最普遍的表现形式。然而,大多数营养项目使用年龄别体重来筛查高危儿童。本研究利用危地马拉农村重度发育迟缓人群中危地马拉营养研究所纵向补充试验(n = 400)的数据,检验了年龄别体重是否是一种有效的筛查工具。发育迟缓的定义为3岁时年龄别身长低于美国国家卫生统计中心标准的-2标准差。使用敏感性和特异性分析以及受试者工作特征曲线,将体重指标(年龄别体重、体重增长速度和身长别体重)与身长(年龄别身长和身长增长速度)以及婴儿早期测量的上臂围和头围进行比较。在预测发育迟缓方面,身长指标明显优于体重指标(Zda检验),而且增长速度始终比已达到的生长水平差。6个月时的年龄别身长表现最佳,其次是3个月时的年龄别身长,以及6个月和3个月时的年龄别体重。增长速度、身长别体重和围度都是发育迟缓的不良预测指标。使用<-1标准差的临界值,3个月时的年龄别身长是早期发现生长发育不良的最佳筛查指标。因此,目前使用年龄别体重进行筛查会导致很大比例的高危儿童被漏筛,这极大地限制了营养干预措施产生影响的潜力。