在单个青蛙肌肉纤维早期张力上升过程中，僵硬度的发展先于横桥附着。
Development of stiffness precedes cross-bridge attachment during the early tension rise in single frog muscle fibres.
作者信息
Bagni M A, Cecchi G, Colomo F, Garzella P
机构信息
Dipartimento di Scienze Fisiologiche, Università degli Studi di Firenze, Italy.
出版信息
J Physiol. 1994 Dec 1;481 ( Pt 2)(Pt 2):273-8. doi: 10.1113/jphysiol.1994.sp020437.
Abstract
- Force responses to ramp stretches were recorded in single muscle fibres isolated from the lumbricalis muscle of the frog. Stretches were applied at rest and at progressively increasing times after a single stimulus. 2. The increase of fibre stiffness that precedes tension development has a 'static' component that accounts for the whole fibre stiffness increase during the latent period and at very low tension at the beginning of the twitch. 3. Static stiffness increase was not affected by 2,3-butanedione-2-monoxime, a drug that almost completely inhibited twitch tension. 4. Static stiffness increased approximately 5-fold as the sarcomere length was increased from 2.1 to 2.84 microns. 5. These results suggest that static fibre stiffness increase is not attributable to the formation of non-force-generating cross-bridges.
摘要
- 在从青蛙蚓状肌分离出的单根肌纤维中记录对斜坡拉伸的力反应。在静息状态以及单次刺激后逐渐增加的时间点施加拉伸。2. 在张力发展之前纤维刚度的增加具有一个“静态”成分，该成分解释了潜伏期以及收缩初期非常低张力时整个纤维刚度的增加。3. 静态刚度的增加不受2,3 - 丁二酮 - 2 - 一肟的影响，该药物几乎完全抑制收缩张力。4. 随着肌节长度从2.1微米增加到2.84微米，静态刚度增加了约5倍。5. 这些结果表明，静态纤维刚度的增加并非归因于非产生力的横桥的形成。
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