Nishimura Y, Nakata H, Maeda H, Yokoyama M
Department of Respiratory Disease, Takatsuki General Hospital, Osaka, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1995 Mar;33(3):300-5.
To study the factors related to bone mineral content (BMC) in patients with bronchial asthma (BA), we measured BMC of the whole body, bone mineral density (BMD) in the second, third, and fourth lumbar vertebrae (by dual energy X-ray absorptiometry, DXA XR-26, Norland), and pulmonary function in patients with BA. Subjects were 103 patients with BA and 194 age-matched normal controls. There was no significant difference in BMC or BMD between patients with BA and controls. In patients with BA, there was no significant difference in BMC or BMD between those who were taking steroids and those who were not. BMC and BMD were significantly correlated with age, body weight, VC, %VC, and FEV1, but not with the duration of steroid administration or the total steroid dose administered. These results suggest that patients with BA have normal BMC and that steroid administration does not affect bone mineral loss in such patients.
为研究支气管哮喘（BA）患者骨矿物质含量（BMC）的相关因素，我们测量了BA患者的全身BMC、第二、三、四腰椎的骨矿物质密度（BMD）（采用双能X线吸收法，DXA XR - 26，Norland）以及肺功能。研究对象为103例BA患者和194例年龄匹配的正常对照者。BA患者与对照组之间的BMC或BMD无显著差异。在BA患者中，服用类固醇药物者与未服用者之间的BMC或BMD也无显著差异。BMC和BMD与年龄、体重、肺活量（VC）、VC百分比（%VC）和第一秒用力呼气容积（FEV1）显著相关，但与类固醇药物给药持续时间或给药总剂量无关。这些结果表明，BA患者的BMC正常，且类固醇药物给药不影响此类患者的骨矿物质流失。
