Nishimura Y, Nakata H, Matsubara M, Maeda H, Yokoyama H
Department of Respiratory Disease, Takatsuki General Hospital, Osaka, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1993 Dec;31(12):1548-52.
Body weight loss is often observed in patients with chronic obstructive pulmonary disease (COPD). Bone mineral loss has also been reported in COPD, but the mechanisms are not well determined. To elucidate what factors influence on bone mineral content in COPD patients, we measured bone mineral content (BMC) by dual energy X-ray absorptiometry (DXA) (XR-26, Norland), pulmonary function, and ten minute walk distance (TMD) in Japanese elderly male patients with COPD. The subjects were 21 male patients with COPD (72.6 +/- 9.5 years) and 18 age-matched male normal individuals (66.5 +/- 9.5 years). COPD patients showed significantly (p < 0.05) lower BMC (1.82 +/- 0.33, 2.27 +/- 0.35 kg, respectively) compared with age-matched controls. BMC was significantly correlated with body weight and TMD (r = 0.71, r = 0.51, respectively). These results demonstrate that lower body weight and decreased exercise capacity account for the significantly lower bone mineral content of our COPD patients and that COPD patients with body weight loss may be at high risk for osteoporotic fracture.
慢性阻塞性肺疾病（COPD）患者常出现体重减轻。COPD患者也有骨矿物质流失的报道，但其机制尚未完全明确。为了阐明哪些因素影响COPD患者的骨矿物质含量，我们采用双能X线吸收法（DXA）（Norland公司的XR - 26型）测量了日本老年男性COPD患者的骨矿物质含量（BMC）、肺功能和10分钟步行距离（TMD）。研究对象为21例男性COPD患者（72.6±9.5岁）和18例年龄匹配的男性正常个体（66.5±9.5岁）。与年龄匹配的对照组相比，COPD患者的BMC显著降低（分别为1.82±0.33、2.27±0.35 kg，p < 0.05）。BMC与体重和TMD显著相关（r分别为0.71和0.51）。这些结果表明，体重降低和运动能力下降是导致我们研究的COPD患者骨矿物质含量显著降低的原因，体重减轻的COPD患者可能有骨质疏松性骨折的高风险。
