McLaurin J A, Yong V W
Montreal Neurological Institute, McGill University, Quebec, Canada.
Neurol Clin. 1995 Feb;13(1):23-49.
Although it was initially thought to be a passive structure, the oligodendrocyte and myelin unit is now considered highly dynamic with many important functions beyond its role in myelination. Inhibitors of neurite growth can be localized to oligodendrocyte and myelin, highlighting the importance of oligodendrocytes in general CNS maintenance and in neuronal regeneration following many types of CNS insults. Understanding of the genesis of oligodendrocytes and myelin is increasing and will surely lead to better strategies to treat demyelinating diseases including MS.
尽管少突胶质细胞和髓磷脂单元最初被认为是一种被动结构，但现在它被视为具有高度动态性，除了在髓鞘形成中的作用外，还具有许多重要功能。神经突生长抑制剂可定位于少突胶质细胞和髓磷脂，这突出了少突胶质细胞在中枢神经系统整体维持以及多种中枢神经系统损伤后神经元再生中的重要性。对少突胶质细胞和髓磷脂起源的认识正在不断增加，这必将带来更好的策略来治疗包括多发性硬化症在内的脱髓鞘疾病。
