Gasparian E G, Nersesian S A, Volkova E A, Kriuchkova Z V, Nassur S, Kuz'mina M M
Probl Endokrinol (Mosk). 1994 Nov-Dec;40(6):17-8.
Blood serum fructosamine level were measured on an empty stomach in 97 normal subjects and subjects with various disorders of carbohydrate metabolism (the so-called "pre-diabetes" and changed glucose tolerance) in order to elucidate the significance of this factor as a marker of such disorders. Fructosamine concentrations were for the first time measured in children whose parents suffered from insulin-dependent or noninsulin-dependent diabetes mellitus. The content of fructosamine on an empty stomach was found to depend on the degree of carbohydrate metabolism disorders, increasing with the progress of these disorders. The findings permit a conclusion on the possibility of using fructosamine as a marker for the diagnosis of "pre-diabetes" in subjects with its levels of 2.5 to 2.99 mmol/l and of disordered glucose tolerance in those with its levels over 3 mmol/l and glucose level on an empty stomach no more than 6 mmol/l.
对97名正常受试者以及患有各种碳水化合物代谢紊乱（即所谓的“糖尿病前期”和糖耐量改变）的受试者进行空腹血清果糖胺水平检测，以阐明该因素作为此类紊乱标志物的意义。首次对父母患有胰岛素依赖型或非胰岛素依赖型糖尿病的儿童进行果糖胺浓度检测。发现空腹时果糖胺含量取决于碳水化合物代谢紊乱程度，并随这些紊乱的进展而增加。这些发现使得可以得出结论：果糖胺水平在2.5至2.99毫摩尔/升的受试者有可能将其用作诊断“糖尿病前期”的标志物，而果糖胺水平超过3毫摩尔/升且空腹血糖水平不超过6毫摩尔/升的受试者有可能将其用作糖耐量紊乱的标志物。
