Cabane J, Etarian C, Louvet C, Robert A, Blum L, Wattiaux M J, Imbert J C
Service de médecine interne 3, hôpital Saint-Antoine, Paris, France.
Rev Med Interne. 1995;16(3):219-24. doi: 10.1016/0248-8663(96)80696-5.
Disseminated intravascular coagulation (DIC) associated with prostate adenocarcinoma is a bad prognostic sign. Most of the cases are limited to biological abnormalities. Some, however, come to medical attention due to thromboembolic or hemorrhagic complications. We report 4 such cases and review the pertinent literature. The characteristic features are low platelets and coagulation factors in an elderly man. In two out of the four cases, bleeding due to the DIC revealed the cancer. All patients received hormonotherapy and heparin. The worst fate (case 3) was a subacute one with no effect of the drugs and death in a short time. The other cases went into a five- to seven months remission before uncontrollable bleeding led to death. No favorable effect of the chemotherapy was observed. Thus, new treatments are sought for this rare but ominous complication of prostate cancer.
与前列腺腺癌相关的弥散性血管内凝血（DIC）是一种预后不良的征象。大多数病例仅限于生物学异常。然而，有些病例因血栓栓塞或出血并发症而就医。我们报告4例此类病例并复习相关文献。其特征为老年男性血小板和凝血因子水平降低。4例中有2例因DIC出血而发现癌症。所有患者均接受了激素治疗和肝素治疗。最糟糕的情况（病例3）是亚急性的，药物治疗无效且短期内死亡。其他病例在无法控制的出血导致死亡前有5至7个月的缓解期。未观察到化疗有良好效果。因此，正在为前列腺癌这种罕见但凶险的并发症寻找新的治疗方法。
