Hirose R, Taguchi T, Hirata Y, Yamada T, Nada O, Suita S
Department of Pediatric Surgery, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Surgery. 1995 May;117(5):560-9. doi: 10.1016/s0039-6060(05)80256-9.
Small bowel transplantation causes a disturbance of the enteric neural networks after complete extrinsic denervation.
The morphologic changes in the enteric nervous system after transplantation were immunohistochemically investigated in jejunal isografts at 10 days, 100 days, and 400 days after transplantation.
No remarkable differences were revealed concerning the antibodies for general neural markers, vasoactive intestinal polypeptide, substance P, somatostatin, or galanin between controls and isografts. Identical differences were detected in the distribution of nerve fibers containing calcitonin gene-related peptide and catecholamines. In the isografts a partial reduction of calcitonin gene-related peptide-immunopositive fibers was shown. A complete elimination of catecholaminergic nerves was seen in the isografts at 10 and 100 days; however, a sparse distribution of catecholaminergic nerves was observed in the 400-day isograft.
Most intrinsic neural elements are preserved; however, the extrinsic, sympathetic, and sensory nerves are completely disrupted as a consequence of transplantation. Reinnervation of extrinsic nerve fibers could occur in the transplanted small intestine.
小肠移植在完全去除外在神经支配后会导致肠神经网络紊乱。
通过免疫组织化学方法研究移植后10天、100天和400天的空肠同基因移植中肠神经系统的形态学变化。
在对照和同基因移植之间，针对一般神经标志物、血管活性肠肽、P物质、生长抑素或甘丙肽的抗体未显示出显著差异。在含有降钙素基因相关肽和儿茶酚胺的神经纤维分布上检测到相同的差异。在同基因移植中，显示降钙素基因相关肽免疫阳性纤维部分减少。在10天和100天的同基因移植中观察到儿茶酚胺能神经完全消失；然而，在400天的同基因移植中观察到儿茶酚胺能神经呈稀疏分布。
大多数内在神经元件得以保留；然而，由于移植，外在神经、交感神经和感觉神经完全被破坏。移植的小肠中可能会发生外在神经纤维的再支配。
