Lindegaard J C, Studstrup H N, Nielsen O S, von der Maase H
Arhus Kommunehospital, onkologisk afdeling D.
Ugeskr Laeger. 1995 Mar 20;157(12):1660-4.
In Denmark about 40 new cases of cancer of the penis are diagnosed each year. Several studies have retrospectively investigated the treatment results in this rare disease. However, most of these studies include few patients and are difficult to compare because several classification systems have been used. Treatment of the primary tumour consists of local excision, laser surgery, partial/total penectomy or irradiation. The prognosis for early stage disease is apparently independent of the mode of treatment and the specific five-year survival rate is 80-90%. Several centres advise prophylactic treatment of the groin in node negative patients, claiming that the survival thereby is increased. However, the morbidity is considerable and randomized studies are not available. The treatment for metastatic inguinal nodes consists of adenectomy or irradiation. The specific five-year survival rate is 40-50%. Chemotherapy has been used for advanced disease. The response rates are low and the responses are of short duration.
在丹麦,每年约有40例阴茎癌新发病例被诊断出来。多项研究对这种罕见疾病的治疗结果进行了回顾性调查。然而,这些研究大多纳入的患者较少,且由于使用了多种分类系统,难以进行比较。原发性肿瘤的治疗方法包括局部切除、激光手术、部分/全阴茎切除术或放射治疗。早期疾病的预后显然与治疗方式无关,具体的五年生存率为80% - 90%。几个中心建议对淋巴结阴性的患者进行腹股沟预防性治疗,称这样可提高生存率。然而,其发病率相当高,且尚无随机对照研究。转移性腹股沟淋巴结的治疗方法包括淋巴结切除术或放射治疗。具体的五年生存率为40% - 50%。化疗已用于晚期疾病。缓解率较低,且缓解持续时间较短。