Koukol S C, DeHaven J I, Riggs D R, Lamm D L
Robert C. Byrd Health Sciences Center, West Virginia University, Department of Urology, Morgantown 26506-9251, USA.
Urol Res. 1995;22(6):373-6. doi: 10.1007/BF00296878.
Intravesical bacillus Calmette-Guérin (BCG) is widely used for the treatment of transitional cell carcinoma of the bladder. Although it is usually well tolerated, sepsis can occur, which has resulted in at least eight deaths [3]. The survival of Connaught BCG-infected mice treated with single and combination antibiotic and steroid therapy was evaluated. Triple-drug therapy with isoniazid, rifampin, and prednisolone resulted in 53% survival compared with 25% survival in the control group (P = 0.0209). A survival of only 10.5% was observed with treatment using prednisolone alone. This survival was worse than that of the control group (25%), and approached statistical significance (P = 0.0669). Our data suggest that BCG sepsis probably has components of both a hypersensitivity reaction and bacterial sepsis; they support the current use of combination antibiotic and steroid therapy for treatment of BCG sepsis in humans, but argue against treatment with steroids alone.
膀胱内灌注卡介苗（BCG）广泛用于治疗膀胱移行细胞癌。尽管它通常耐受性良好，但仍可能发生败血症，这已导致至少8例死亡[3]。评估了用单一和联合抗生素及类固醇疗法治疗的感染康诺特BCG小鼠的存活率。异烟肼、利福平与泼尼松龙联合治疗的存活率为53%，而对照组为25%（P = 0.0209）。单独使用泼尼松龙治疗的存活率仅为10.5%。该存活率低于对照组（25%），接近统计学显著性（P = 0.0669）。我们的数据表明，BCG败血症可能同时具有超敏反应和细菌性败血症的成分；这些数据支持目前在人类中联合使用抗生素和类固醇疗法治疗BCG败血症，但反对单独使用类固醇治疗。
