Wisselink M A, Koeman J P, Wensing T, de Bruijne J, Willemse T
Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, University of Utrecht, The Netherlands.
Vet Q. 1994 Dec;16(4):199-202. doi: 10.1080/01652176.1994.9694448.
Bilateral uveitis and multiple xanthomas (fat deposits in the skin) are described in a 3.5-year-old ovariohysterectomized female Persian cat. The cat had been treated for 2 years with corticosteroids. Examinations included a routine blood chemistry profile, radiographic examination of the thorax and abdomen, histopathological examination of multiple skin punch biopsies, and analysis of blood lipid components by cellulose-acetate electrophoresis and by preparative ultracentrifugation studies. Total lipid values were 23 g/l. Ultracentrifugation studies indicated strongly elevated VLDL and LDL fractions and a decreased concentration of the HDL fraction. Because of sudden blindness the cat was euthanized at the request of the owner. Autopsy revealed massive atherosclerotic changes in the large abdominal vessels, the wall of the aorta, and the coronary vessels. Although the exact pathogenesis remains uncertain, these unusual findings might be explained by a primary hyperlipoproteinaemia, complicated by long-term use of corticosteroids.
一只3.5岁已接受卵巢子宫切除术的雌性波斯猫出现双侧葡萄膜炎和多处黄瘤（皮肤脂肪沉积）。这只猫已接受皮质类固醇治疗2年。检查包括常规血液生化检查、胸部和腹部的放射检查、多处皮肤打孔活检的组织病理学检查，以及通过醋酸纤维素电泳和制备性超速离心研究对血脂成分进行分析。总脂质值为23 g/l。超速离心研究表明极低密度脂蛋白（VLDL）和低密度脂蛋白（LDL）组分显著升高，高密度脂蛋白（HDL）组分浓度降低。由于突然失明，应主人要求对该猫实施安乐死。尸检显示大腹部血管、主动脉壁和冠状动脉出现大量动脉粥样硬化改变。尽管确切发病机制尚不确定，但这些异常发现可能由原发性高脂蛋白血症解释，并因长期使用皮质类固醇而复杂化。
