Bergmann R L, Schulz J, Günther S, Dudenhausen J W, Bergmann K E, Bauer C P, Dorsch W, Schmidt E, Luck W, Lau S
Pediatric Department, University Hospital, FU Berlin, Germany.
Allergy. 1995 Jan;50(1):65-71. doi: 10.1111/j.1398-9995.1995.tb02484.x.
For screening atopy risk in 6401 (84%) of all infants born during the year 1990 in six obstetric departments of five German cities, cord-blood IgE values were determined with CAP-RAST-FEIA. After cases with elevated IgA values had been excluded, 25% of the values were above the detection limit of 0.35 kU/l, and 8.5% were above 0.9 kU/l. Boys had significantly higher values than girls (P < 0.001). The distribution of values was significantly different for different nationalities of mothers (P < 0.001). The percentage of elevated values (> 0.9 kU/l) increased significantly with the number of close family members with atopic history (P < 0.001). Regarding the atopic history of the father, siblings, and mother separately, only the mother's history had a significant association with the cord-blood IgE class (P < 0.001). The IgE values of 81 twin pairs correlated significantly with a coefficient of r = 0.4909 (P < 0.001). The smoking history of the parents during pregnancy showed an association with cord-blood IgE values (P < 0.02). No significant association could be shown between cord-blood IgE distribution and other variables, i.e., gestational age, birth size, birth modus, Apgar score, cord-blood pH value, neonatal problems, parity, age of the mother, medication during pregnancy, educational level of mother or father, time of year, or obstetric department. It is hypothesized that, in addition to some postpartum contamination or placental transfer of maternal IgE, cord-blood IgE values are also determined by the fetal immunologic reaction to intrauterine exposure to allergens and trigger factors, and by genetic influences.
为筛查1990年在德国五个城市的六个产科部门出生的所有婴儿中6401名（84%）的特应性风险，采用CAP-RAST-FEIA法测定脐血IgE值。排除IgA值升高的病例后，25%的值高于检测限0.35 kU/l，8.5%的值高于0.9 kU/l。男孩的值显著高于女孩（P < 0.001）。母亲不同国籍的情况下，值的分布有显著差异（P < 0.001）。IgE值升高（> 0.9 kU/l）的百分比随有特应性病史的近亲家庭成员数量显著增加（P < 0.001）。分别考虑父亲、兄弟姐妹和母亲的特应性病史，只有母亲的病史与脐血IgE类别有显著关联（P < 0.001）。81对双胞胎的IgE值显著相关，相关系数r = 0.4909（P < 0.001）。父母孕期的吸烟史与脐血IgE值有关联（P < 0.02）。脐血IgE分布与其他变量，即胎龄、出生大小、分娩方式、阿氏评分、脐血pH值、新生儿问题、产次、母亲年龄、孕期用药、父母教育水平、一年中的时间或产科部门之间未显示出显著关联。据推测，除了产后一些母体IgE的污染或胎盘转移外，脐血IgE值还由胎儿对宫内接触过敏原和触发因素的免疫反应以及遗传影响所决定。
