Watt F, Landsberg J, Powell J J, Ede R J, Thompson R P, Cargnello J A
Scanning Proton Microprobe Unit, University of Oxford, UK.
Analyst. 1995 Mar;120(3):789-91. doi: 10.1039/an9952000789.
We have recently developed a technique utilizing the nuclear microscope to analyse accurately the trace element content of hair at concentrations of ppm and to differentiate between the levels within hair and those due to surface contamination. Hair was analysed from four patients with Wilson's disease (systemic copper overload), one patient with sub-acute lead poisoning, and three control subjects, and the concentrations and distributions of lead and copper across the hair shafts were shown. However, there was no increase in the copper content of hair from patients with Wilson's disease compared with those of normal subjects, indicating that the high copper levels of many tissues in this disease are not reflected in hair. In contrast, hair samples from the patient with lead poisoning showed maximum concentrations of 14 (+/-2) micrograms g-1, compared with normal levels of less than 1 micrograms g-1. Further, the composition of the hairs along the shaft reflected the temporal changes of lead levels in the patient during lead elimination.
我们最近开发了一种利用核显微镜的技术，能够准确分析头发中百万分之一浓度的微量元素含量，并区分头发内部的含量水平与表面污染造成的含量水平。对4例威尔逊氏病（全身性铜过载）患者、1例亚急性铅中毒患者和3名对照者的头发进行了分析，并展示了铅和铜在整个发干中的浓度及分布情况。然而，与正常受试者相比，威尔逊氏病患者头发中的铜含量并未增加，这表明该疾病中许多组织的高铜水平并未在头发中体现出来。相比之下，铅中毒患者的头发样本显示最大浓度为14（±2）微克/克，而正常水平低于1微克/克。此外，发干上头发的成分反映了患者在排铅过程中铅水平的时间变化。
