Valensi P, Behar A, Andre P, Wiernsperger N, Attali J R
Service d'Endocrinologie-Diabétologie-Nutrition, Hôpital Jean Verdier, Université Paris-Nord, France.
Angiology. 1995 May;46(5):401-8. doi: 10.1177/000331979504600506.
An experimental work has suggested the efficacy of metformin, an oral antidiabetic agent, on capillary permeability. This agent has been tested in 10 women patients with cyclic edema, 7 of them being obese. The capillary permeability to albumin studied by an isotope test derived from Landis's method was initially increased. After a mean of six-weeks of treatment the albumin retention and an index demonstrating the interstitial protein elimination through the lymph route were significantly improved. Concomitantly, the swelling feelings were reduced in 8 cases and the lower limb edema had decreased or disappeared in 8 of 9 patients who initially presented these symptoms. The effects of metformin are beneficial and have been observed to be independent of glycemic change. The results suggest a special effect of this agent on the microcirculation. Nevertheless, a controlled study is required.
一项实验研究表明，口服抗糖尿病药物二甲双胍对毛细血管通透性具有疗效。该药物已在10名患有周期性水肿的女性患者中进行了测试，其中7名患者肥胖。通过源自兰迪斯方法的同位素试验研究的白蛋白毛细血管通透性最初有所增加。经过平均六周的治疗后，白蛋白潴留以及通过淋巴途径显示间质蛋白清除的指标得到了显著改善。同时，8例患者的肿胀感减轻，9例最初出现这些症状的患者中有8例下肢水肿减轻或消失。二甲双胍的作用是有益的，且已观察到其作用与血糖变化无关。结果表明该药物对微循环有特殊作用。然而，仍需要进行对照研究。
