牛奶和食物对依诺沙星吸收的影响。
Effects of milk and food on the absorption of enoxacin.
作者信息
Lehto P, Kivistö K T
机构信息
Department of Pharmacology, University of Turku, Finland.
出版信息
Br J Clin Pharmacol. 1995 Feb;39(2):194-6. doi: 10.1111/j.1365-2125.1995.tb04431.x.
Abstract
The effects of milk and a standard breakfast on the oral absorption of enoxacin were evaluated in eight healthy volunteers in a randomized, balanced, four-way crossover study. After an overnight fast, 400 mg enoxacin was given with water, milk, a breakfast or with a breakfast and milk. The extent of enoxacin absorption was not affected by any of the three treatments, and no statistically significant changes were found with respect to peak plasma enoxacin concentration or time to peak. We conclude that enoxacin can be taken together with food and dairy products.
摘要
在一项随机、均衡、四交叉研究中，对8名健康志愿者评估了牛奶和标准早餐对依诺沙星口服吸收的影响。经过一夜禁食后，给予400毫克依诺沙星，分别用水、牛奶、早餐或早餐加牛奶送服。三种处理中的任何一种都未影响依诺沙星的吸收程度，血浆依诺沙星峰浓度或达峰时间也未发现有统计学意义的变化。我们得出结论，依诺沙星可与食物和乳制品一起服用。
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