Füredi Petra, Pápai Katalin, Budai Marianna, Ludányi Krisztina, Antal István, Klebovich Imre
Semmelweis Egyetem Gyógyszerészeti Intézet, Budapest.
Acta Pharm Hung. 2009;79(2):81-7.
Although food-drug interactions have been studied extensively in recent years, in the light of the complex nature of these interactions general guideline for clinical practice can not be given. Drug interactions with food (containing multivalent metal ions or protein) can have an influence on drug absorption with widely variety of mechanism, resulting in changes in both the rate and extent of bioavailability. Food-drug interaction can be important in the clinical practice. Studies of the interaction between food/juice and fluoroquinolones have produced conflicting results. A number of studies give evidence that fluoroquinolones forming slightly soluble complex with metal ions of food show reduced bioavailability. In the same time, concurrent ingestion of food/ juice with fluoroquinolones has been shown not to interfere with their absorption to a clinically significant degree.
尽管近年来对食物-药物相互作用进行了广泛研究，但鉴于这些相互作用的复杂性，无法给出临床实践的通用指南。药物与食物（含有多价金属离子或蛋白质）的相互作用可通过多种机制影响药物吸收，导致生物利用度的速率和程度都发生变化。食物-药物相互作用在临床实践中可能很重要。食物/果汁与氟喹诺酮类药物之间相互作用的研究结果相互矛盾。一些研究表明，氟喹诺酮类药物与食物中的金属离子形成微溶性复合物会导致生物利用度降低。同时，氟喹诺酮类药物与食物/果汁同时摄入已被证明在临床上不会对其吸收产生显著干扰。
