食物对洛美沙星吸收的影响。
Effect of food on absorption of lomefloxacin.
作者信息
Hooper W D, Dickinson R G, Eadie M J
机构信息
Department of Medicine, University of Queensland, Royal Brisbane Hospital, Herston, Australia.
出版信息
Antimicrob Agents Chemother. 1990 Sep;34(9):1797-9. doi: 10.1128/AAC.34.9.1797.
Abstract
Twelve subjects participated in an open-label, single-dose, balanced three-way crossover study in which the absorptions of lomefloxacin were compared following (i) an overnight fast, (ii) a carbohydrate meal, and (iii) a high-fat meal. The time to peak concentration of lomefloxacin was delayed, but peak concentration in plasma and amount of drug absorbed were unchanged following both meals.
摘要
12名受试者参与了一项开放标签、单剂量、平衡三向交叉研究，该研究比较了洛美沙星在以下三种情况下的吸收情况：（i）隔夜禁食后；（ii）进食碳水化合物餐后；（iii）进食高脂餐后。洛美沙星的达峰时间延迟，但两餐后血浆中的峰浓度和药物吸收量均未改变。
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本文引用的文献
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Clin Pharmacokinet. 1978 Sep-Oct;3(5):337-51. doi: 10.2165/00003088-197803050-00001.
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