Castella A P, Bercher L, Zografos L, Egger E, Herbort C P
Department of Ophthalmology, Hôpital Jules Gonin, University of Lausanne, Switzerland.
Br J Ophthalmol. 1995 Apr;79(4):354-7. doi: 10.1136/bjo.79.4.354.
Aqueous flare was used to determine the frequency and amount of blood-aqueous barrier breakdown and correlate it with tumour variables.
Aqueous flare was analysed prospectively by laser flare photometry in 139 consecutive patients seen in the oncology unit for choroidal melanoma. Both eyes of patients were examined with a laser flare cell meter in a standard fashion.
Mean flare difference between healthy and tumour eyes was 3.01 (SD 2.5) photons per millisecond (ph/ms) in 32 cases of small melanomas (p < 0.0001), 10.74 (13.9) ph/ms in 92 cases of medium and large melanomas (p < 0.0001), and 19.23 (11.8) ph/ms in 15 cases of very large melanomas (p < 0.0001). This mean differential flare was significantly higher in medium and large than in small melanomas (p < 0.002) and in very large melanomas than in medium and large melanomas (p < 0.028). A difference of > or = 7 ph/ms between affected and healthy eyes was noted in 70 of 139 melanomas (50.4%). It was found in 3/32 small melanomas (9.4%), in 53/92 medium and large melanomas (57.6%), and in 14/15 very large melanomas (93.3%).
Multiple linear regression analysis showed that flare was most strongly correlated with tumour volume (r = 0.43; p < 0.0001) and tumour height (r = 0.41; p < 0.0008).
使用房水闪光来确定血-房水屏障破坏的频率和程度，并将其与肿瘤变量相关联。
对肿瘤科室连续收治的139例脉络膜黑色素瘤患者，采用激光闪光光度计对房水闪光进行前瞻性分析。用激光闪光细胞仪以标准方式检查患者的双眼。
32例小黑色素瘤患者中，健康眼与患眼的平均闪光差异为每毫秒3.01（标准差2.5）个光子（ph/ms）（p<0.0001）；92例中、大黑色素瘤患者中为10.74（13.9）ph/ms（p<0.0001）；15例非常大的黑色素瘤患者中为19.23（11.8）ph/ms（p<0.0001）。中、大黑色素瘤的平均闪光差异显著高于小黑色素瘤（p<0.002），非常大的黑色素瘤高于中、大黑色素瘤（p<0.028）。139例黑色素瘤患者中，70例（50.4%）患眼与健康眼的差异≥7 ph/ms。在32例小黑色素瘤中有3例（9.4%）出现，92例中、大黑色素瘤中有53例（57.6%）出现，15例非常大的黑色素瘤中有14例（93.3%）出现。
多元线性回归分析显示，闪光与肿瘤体积（r = 0.43；p < 0.0001）和肿瘤高度（r = 0.41；p < 0.0008）的相关性最强。
