Sawa M
Section of Corneal Transplantation, University Hospital, University of Tokyo School of Medicine, Japan.
Jpn J Ophthalmol. 1990;34(3):346-63.
Clinical application of the laser flare-cell meter was described. The instrument was developed for concurrent quantitative determinations of the flare and number of cells in the aqueous humor. Diurnal variations were demonstrated in the aqueous flare, and also an increase in the flare with increasing age. The effects of drugs on aqueous humor dynamics were also studied. Orally administered 500 mg of carbonic anhydrase inhibitor reduced the aqueous humor formation by one-third. Concurrent study with the laser flare-cell meter and slit-lamp microscopy in uveitis cases has revealed that the former instrument is superior to the latter in making a quantitative evaluation of inflammation in the anterior segment of the eye. A follow-up study of postoperative inflammation was performed in patients undergoing extracapsular cataract extraction with posterior chamber intraocular lens implantation. Cases with uneventful postoperative course showed intense flare on the first postoperative day followed by a rapid decrease. Cases with inflammation and fibrin had high aqueous flare which showed an increase even before detection of fibrin in the aqueous by slit-lamp microscopy. Topical 0.5% indomethacin treatment was shown to be effective in suppressing the postoperative increase in aqueous flare but had little effect on cell count. In cases undergoing Argon laser trabeculoplasty, the aqueous flare in the treated eyes was determined to be significantly higher than that in the fellow eyes for four weeks postoperatively (P less than 0.05). The laser flare-cell meter has made it possible to determine the flare and number of cells in the aqueous humor quantitatively. This capability differentiates the instrument from the slit-lamp microscope as well as the instruments previously developed for similar purposes. The laser flare-cell meter is a newly developed useful tool to investigate the pathophysiology of the eye.
描述了激光闪光细胞仪的临床应用。该仪器用于同时定量测定房水中的闪光和细胞数量。研究发现房水闪光存在日变化，且闪光随年龄增长而增加。还研究了药物对房水动力学的影响。口服500毫克碳酸酐酶抑制剂可使房水生成减少三分之一。在葡萄膜炎病例中，将激光闪光细胞仪与裂隙灯显微镜同时进行研究发现，在对眼前节炎症进行定量评估方面，前者优于后者。对接受白内障囊外摘除联合后房型人工晶状体植入术的患者进行了术后炎症的随访研究。术后过程平稳的病例在术后第一天出现强烈闪光，随后迅速下降。有炎症和纤维蛋白形成的病例房水闪光值高，甚至在裂隙灯显微镜检测到房水中有纤维蛋白之前就已升高。局部应用0.5%吲哚美辛治疗可有效抑制术后房水闪光增加，但对细胞计数影响不大。在接受氩激光小梁成形术的病例中，术后四周内，治疗眼的房水闪光值明显高于对侧眼（P<0.05）。激光闪光细胞仪能够定量测定房水中的闪光和细胞数量。这一功能使该仪器有别于裂隙灯显微镜以及之前为类似目的开发的仪器。激光闪光细胞仪是一种新开发的用于研究眼病理生理学的有用工具。
