Moriarty A P, Spalton D J, Moriarty B J, Shilling J S, Ffytche T J, Bulsara M
Department of Ophthalmology, St. Thomas's Hospital, London, England.
Am J Ophthalmol. 1994 Jun 15;117(6):768-71. doi: 10.1016/s0002-9394(14)70320-4.
We measured the breakdown of the blood-aqueous barrier in 63 patients with diabetes (126 eyes) by using a laser flare meter. Of 126 eyes, 40 had no retinopathy, 34 had proliferative retinopathy, 24 had regressed proliferative retinopathy, 14 had background retinopathy, and 14 had maculopathy. Eyes were classified into one category only. Mean flare was greater for proliferative retinopathy compared to background retinopathy (P = .0065), no retinopathy (P = .0001), and maculopathy (P = .0189). Flare values were greater for regressed proliferative retinopathy compared to no retinopathy (P = .0118) (paired Student's t-test). Diabetic eyes without demonstrable retinopathy still had higher flare values than control eyes without diabetes. The length of diabetes was greater for those eyes with proliferative diabetic retinopathy (P = .0195), regressed proliferative diabetic retinopathy (P = .0625), and background diabetic retinopathy (P = .006) compared to those with no retinopathy. No significant difference was noted in duration of diabetes for eyes with diabetic maculopathy when compared to those with no retinopathy (P = .5788). Breakdown of the blood-aqueous barrier precedes the development of retinopathy, and the more severe proliferative forms have greater blood-aqueous barrier dysfunction.
我们使用激光散射仪测量了63例糖尿病患者（126只眼）的血-房水屏障破坏情况。在这126只眼中，40只无视网膜病变，34只患有增殖性视网膜病变，24只患有增殖性视网膜病变消退期，14只患有背景性视网膜病变，14只患有黄斑病变。每只眼仅归入一个类别。与背景性视网膜病变（P = 0.0065）、无视网膜病变（P = 0.0001）和黄斑病变（P = 0.0189）相比，增殖性视网膜病变的平均散射光更强。与无视网膜病变相比，增殖性视网膜病变消退期的散射光值更高（P = 0.0118）（配对t检验）。无明显视网膜病变的糖尿病眼的散射光值仍高于无糖尿病的对照眼。与无视网膜病变的眼相比，患有增殖性糖尿病视网膜病变（P = 0.0195）、增殖性糖尿病视网膜病变消退期（P = 0.0625）和背景性糖尿病视网膜病变（P = 0.006）的眼的糖尿病病程更长。与无视网膜病变的眼相比，患有糖尿病黄斑病变的眼的糖尿病病程无显著差异（P = 0.5788）。血-房水屏障破坏先于视网膜病变的发生，且增殖性病变越严重，血-房水屏障功能障碍越明显。
