Pratt R D, Bradley J S, Loubert C, LaRocco A, McNeal R M, Newbury R O, Sawyer M H
University of California, San Diego, La Jolla 92093, USA.
Clin Infect Dis. 1995 Feb;20(2):450-3. doi: 10.1093/clinids/20.2.450.
We report two cases of intense, generalized rhabdomyolysis complicating varicella-zoster virus (VZV) infections, one in an adolescent and one in a young adult male. In both cases, myoglobinuria and weakness of large muscle groups developed within 5 days of the onset of vesicular lesions. A muscle biopsy from one of the individuals showed muscle fiber necrosis in the absence of acute inflammatory infiltrates or vasculitis. Culture of the muscle biopsy specimen for VZV was negative; however, the VZV genome was detected by the polymerase chain reaction. Both patients recovered fully after treatment with hydration therapy alone.
我们报告了两例严重的全身性横纹肌溶解症，这是水痘-带状疱疹病毒（VZV）感染的并发症，一例发生在青少年，另一例发生在青年男性。在这两例病例中，在水疱性皮损出现后的5天内均出现了肌红蛋白尿和大肌群无力。其中一名患者的肌肉活检显示存在肌纤维坏死，但无急性炎性浸润或血管炎。对肌肉活检标本进行VZV培养结果为阴性；然而，通过聚合酶链反应检测到了VZV基因组。两名患者仅接受水化治疗后均完全康复。
