Benatar A, Clarke J, Silverman M
Department of Paediatrics and Neonatal Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London.
Arch Dis Child Fetal Neonatal Ed. 1995 Jan;72(1):F14-9. doi: 10.1136/fn.72.1.f14.
A total of 45 examinations on 30 premature infants with chronic lung disease (CLD) of prematurity were made using Doppler echocardiography. Pulmonary systolic time intervals and tricuspid regurgitant velocity were measured to assess the prevalence of pulmonary hypertension and short term responsiveness of the pulmonary circulation to oxygen. Twelve preterm infants matched for gestational age, served as controls. Tricuspid regurgitation (TR) was detected in 14 of the patients. Eleven of those with TR had pulmonary hypertension, of whom eight responded to oxygen treatment. Of the remaining three patients with 'fixed' pulmonary hypertension, one subsequently died. The detection of TR was the basis of the preferred method for measuring pulmonary artery pressure (Ppa) non-invasively, but the degree of correlation between the Ppa estimated from TR and pulmonary systolic time intervals was high (r = -0.84, p = 0.001). In the absence of TR, systolic time intervals are an effective way to monitor pulmonary artery pressure in infants with CLD. Without these measurements, it would have been impossible to predict which subjects had pulmonary hypertension, and which might respond to oxygen treatment.
采用多普勒超声心动图对30例早产慢性肺疾病（CLD）早产儿进行了共计45次检查。测量了肺收缩期时间间期和三尖瓣反流速度，以评估肺动脉高压的患病率以及肺循环对氧气的短期反应性。选取12例孕周匹配的早产儿作为对照。14例患者检测到三尖瓣反流（TR）。其中11例TR患者患有肺动脉高压，其中8例对氧疗有反应。其余3例“顽固性”肺动脉高压患者中，1例随后死亡。TR的检测是无创测量肺动脉压（Ppa）首选方法的基础，但根据TR估计的Ppa与肺收缩期时间间期之间的相关性很高（r = -0.84，p = 0.001）。在没有TR的情况下，收缩期时间间期是监测CLD婴儿肺动脉压的有效方法。如果没有这些测量，就不可能预测哪些受试者患有肺动脉高压，以及哪些可能对氧疗有反应。
