Carrick J B, Schnellmann R G, Moore J N
Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens 30602, USA.
Shock. 1994 Dec;2(6):421-6. doi: 10.1097/00024382-199412000-00006.
The effect of 8 weeks of feeding diets enriched with corn oil, linseed oil, or menhaden oil on endotoxin- and calcium ionophore (A23187)-induced tumor necrosis factor (TNF) and eicosanoid synthesis by rat peritoneal macrophages was determined. The fatty acid composition of macrophage phospholipids and TNF activity and eicosanoid synthesis in response to endotoxin and A23187 were determined. The ratio of omega-6/omega-3 fatty acids in macrophages from linseed oil or menhaden oil-fed rats decreased approximately 24- and 55-fold, respectively. Basal and endotoxin-induced synthesis of TNF was increased by ingestion of the menhaden oil diet but not by the linseed oil diet. Ingestion of the menhaden oil and linseed oil diets significantly reduced basal, endotoxin-, and A23187-induced synthesis of eicosanoids compared with the corn oil group. Ingestion of the menhaden oil diet resulted in a greater decrease in eicosanoid synthesis than the linseed oil diet.
研究了喂食富含玉米油、亚麻籽油或鲱鱼油的日粮8周对大鼠腹腔巨噬细胞内毒素和钙离子载体（A23187）诱导肿瘤坏死因子（TNF）及类花生酸合成的影响。测定了巨噬细胞磷脂的脂肪酸组成以及对内毒素和A23187的TNF活性及类花生酸合成。来自喂食亚麻籽油或鲱鱼油大鼠的巨噬细胞中ω-6/ω-3脂肪酸比例分别降低了约24倍和55倍。摄入鲱鱼油日粮可增加基础和内毒素诱导的TNF合成，但摄入亚麻籽油日粮则无此作用。与玉米油组相比，摄入鲱鱼油和亚麻籽油日粮显著降低了基础、内毒素和A23187诱导的类花生酸合成。摄入鲱鱼油日粮比摄入亚麻籽油日粮导致类花生酸合成的降低幅度更大。
