Zhang K H, Wang H J, Fu J
Shcool of Stomatology, Beijing Medical University.
Zhonghua Kou Qiang Yi Xue Za Zhi. 1994 Sep;29(5):266-8, 319.
The successful rate in producing oral candidiasis of the animal is not high. By utilizing: (1) fresh cell-line isolated from the oral cavity of the patient suffering from oral candidiasis and passing twice in rabbits and re-isolated to increase its toxicity; and (2) expanding the area of examination, the authors successfully (100%) produced oral candidiasis in Wistar rats. The specimens are studied histologically on its nature of whether it is a precancerous lesion or not.
使动物发生口腔念珠菌病的成功率不高。通过利用:(1)从患口腔念珠菌病患者口腔分离的新鲜细胞系,在兔体内传代两次并重新分离以增加其毒性;(2)扩大检查范围,作者成功地(100%)使Wistar大鼠发生了口腔念珠菌病。对标本进行组织学研究,以确定其是否为癌前病变。