Culine S, Bekradda M, Terrier-Lacombe M J, Droz J P
Department of Medicine, Institut Gustave-Roussy, Villejuif, France.
Eur Urol. 1995;27(2):138-41. doi: 10.1159/000475145.
The sarcomatoid variant of renal cell carcinoma is a clinical entity with local and metastatic aggressiveness which translates to short survival time. Fourteen cases of patients that fit strict criteria for sarcomatoid cell carcinoma and convenient clinical data for treatment and follow-up were retrospectively selected among 1,235 patients treated at the Institut Gustave-Roussy over a 17-year period. Thirteen patients underwent initial nephrectomy. Local recurrence or distant metastases occurred in all patients. Only 1 patient was treated by surgical removal of a unique lung metastasis and is currently alive with no evidence of disease. No response was observed in all 4 patients treated with alpha-interferon. Chemotherapy was administered in 10 patients, 8 of whom received doxorubicin-based regimens. The survival was 20, 29 and 60 months for the 3 responding patients as compared to a median of 9 months for patients with progressive disease. Further phase II studies are warranted to define the real impact of chemotherapy in this disease.
肾细胞癌的肉瘤样变体是一种具有局部和转移侵袭性的临床实体，这导致生存时间较短。在古斯塔夫 - 鲁西研究所17年间治疗的1235例患者中，回顾性选择了14例符合肉瘤样细胞癌严格标准且有方便的治疗及随访临床数据的患者。13例患者接受了初始肾切除术。所有患者均出现局部复发或远处转移。只有1例患者通过手术切除了唯一的肺转移灶，目前存活且无疾病证据。4例接受α-干扰素治疗的患者均未观察到反应。10例患者接受了化疗，其中8例接受了以阿霉素为基础的方案。3例有反应的患者的生存期分别为20、29和60个月，而疾病进展患者的中位生存期为9个月。有必要进行进一步的II期研究以确定化疗在该疾病中的实际影响。
