Galaktionov K, Jessus C, Beach D
Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, New York 11724, USA.
Genes Dev. 1995 May 1;9(9):1046-58. doi: 10.1101/gad.9.9.1046.
The Ras and Raf1 proto-oncogenes transduce extracellular signals that promote cell growth. Cdc25 phosphatases activate the cell division cycle by dephosphorylation of critical threonine and tyrosine residues within the cyclin-dependent kinases. We show here that Cdc25 phosphatase associates with raf1 in somatic mammalian cells and in meiotic frog oocytes. Furthermore, Cdc25 phosphatase can be activated in vitro in a Raf1-dependent manner. We suggest that activation of the cell cycle by the Ras/Raf1 pathways might be mediated in part by Cdc25.
